Follicular Phase, Waves, Oogenesis, and Ovulation Review Quiz

1. Under which of the following conditions does estradiol have positive feedback. (check all that apply)
absence of the corpus luteum
 when a dominant follicle is present
 when inhibin is high
 when progesterone is low or absent
2. Where is progesterone produced?
in granulosa cells
 in theca interna cells
 in small or large luteal cells
 in secondary follicles

3. A primary folicle has multiple layers of follicle cells which are called theca and granulosa cells.
True
 False

4. The growth of a primordial to primary to secondary follicle is dependent on FSH.
True
 False

5. A follicle which no longer converts androgen to estrogen will begin to secrete androgen (testosterone) that will trigger further atresia of this follicle.
True
 False

6. During recruitment, which of the following occur? (check all that apply)
An increase in circulating FSH.
 Presence of FSH receptors on granulosa cells.
 Presence of LH receptors on granulosa cells.
 Presence of LH receptors on theca cells.
 Secretion of inhibin.
 A decrease in circulating FSH.
 Estrogen production by granulosa cells of follicles.

7. During selection which of the following occur? (check all that apply)
An increase in circulating FSH.
 Presence of FSH receptors on granulosa cells.
 Presence of LH receptors on granulosa cells.
 Presence of LH receptors on theca cells.
 Secretion of inhibin.
 A decrease in circulating FSH.
 Estrogen production by granulosa cells of follicles.
8. If a cow can have 2 or 3 follicluar waves in an estrous cycle, how many does a human have during a menstrual cycle?
1
 2
 3
 none

9. If the dominant follicle is destroyed for example by ultrasound guided follicular aspiration or by atresia, which of the following are true? (check all that apply)
Inhibin production will increase.
 estradiol production will increase
 FSH levels will increase due to a decrease of inhibin
 recruitment will be stimulated
 ovulation will occur shortly.

10. FSH increases at about the time the first dominant follicle of the estrous cycle reaches maximal size because inhibin production declines at this time.
True
 False
11. In the ovary, which of the following cells will divide mitotically.
oogonia
 primary oocyte
 secondary oocyte
 first polar body
12. In which of the following species does ovulation of a secondary oocyte occur? (check all that apply)
bovine
 ovine
 porcine
 equine
 dog
 cat

13. The germinal vesicle of a primary oocyte is the nucleus of that oocyte.
True
 False

14. At which stage of prophase does the primary oocyte become arrested and progresses no further in meiosis until puberty?
leptotene
 leptotene
 dipliotene or dictyotene
 zygotene

15. The corona radiata have gap junctions with the primary oocyte of the preovulatory follicle. The gap junctions allow the oocyte maturation inhibitor to be transfered to the oocyte to maintain oocyte arrest.
True
 False

16. The effect of Oocyte Maturation Inhibitor (OMI) is to maintain high levels of cAMP in the oocyte and thereby ensure the oocyte remains in meiotic arrest.
True
 False

17. Cumulus cells expand around the oocyte in response to FSH and do so because they produce hyaluronic acid and proteins.
True
 False

18. The LH surge causes the breakdown of tight junctions between corona radiata cells and the oocyte.
True
 False

19. During the ovulatory process, the role of prostaglandin is to: (check all that apply)
to stimulate progesterone production.
 to stimulate synthesis of plasminogen activator.
 stimulate collagenase activation.
 stimulates contration of the smooth muscle surrounding the follicle.
 stimulates vascular permeability.
 causes the oocyte to separate from the follicular wall.
 stimulates the formation of inactive collagenase.

20. During the ovulatory process, the role of progesterone is to: (check all that apply).
to stimulate plasmin synthesis.
 to stimulate synthesis of plasminogen activator.
 stimulate collagenase activation.
 stimulate contraction of smooth muscle surrounding the follicle.
 stimulate vascular permeability.
 causes the oocyte to separate from the follicular wall.
 stimulates the formation of inactive collagenase.

21. PGF is used to manipulate ovulation by:
Choice 1 causing regression of the corpus luteum.
 Choice 2 simulating hormones produced by CL.
 Choice 3 directly stimulating ovulation
 Choice 4 none of the above.

22. GnRH is used to manipulate ovulation by
Choice 1 causing regression of the CL.
 Choice 2 stimulating hormones produced by the CL.
 Choice 3 directly stimulating ovulation.
 Choice 4 none of the above.

23. Progestins used to manipulate ovulation by
Choice 1 causing regression of the CL.
 Choice 2 simulating hormones produced by the CL.
 Choice 3 directly stimulates ovulation.
 Choice 4 none of the above.