updated 10/16/06
Animal Sciences 434 - Control of Female Cycles
Objectives:
- To understand the endocrine mechanisms controling both the enstrual and menstrual cycles.
- Gain an understanding of how hormones are used to manipulate female cycles.
Terminology:
- Luteolysis - the process by which the corpus luteum undergoes regression
- anti-hormone - this substance binds to a specific hormone receptor and prevents the native hormone from binding to that receptor. The anti-hormone may not activate the receptor or may be a weak version of the native hormone in terms of its response in the target cell.
- analogue - has similar activity to something but is chemical different.
- Lutalyse - this is PGF2a
- Estrumate - a longer acting analogue of PGF2a
- MGA - an oral progestin used in cattle and sheep
- Regu-Mate and Matrix - an oral progestin given mainly to horses or pigs respectively
- CIDR - a vaginal progestin delivery device used in cattle and sheep
- PG600 - a combination of HCG and eCG designed for swine use but also used in sheep
- Clomiphine Citrate - an anti-estrogen used in humans
- Pergonal - hMG used in humans
Laboratory Activities:
- Getting ready for lab: None this week but be sure to review below what you will be doing in and out of class.
- Cycle manipulation: Understand the basis for manipulation of cycles as well as some of the drugs that can be used.
- Cases on cycle manipulation: Groups will be assigned a case to examine cycle manipulation and will record a podcast presentation regarding their case. In addition 3 consultant worksheets must be completed and added below the question 8.
- Experiments on cycle manipulation: Examine the results from acutal synchronization experiments in cattle and sows (questions 1 - 8 in this section).