Animal Sciences > Faculty Index > Kirkpatrick

	Brian Kirkpatrick, Professor            Department of Animal Sciences; Department of Dairy Science Animal Science Bldg. 1675 Observatory Drive Madison, WI 53706 Telephone: 608.263.4323 Fax: 608.262.5157 email: bwkirkpa@wisc.edu PubMed citation

Education:

B.S. Iowa State University, Animal Science 1979
M.S. University of Wisconsin-Madison, Meat & Animal Sciences/Animal Breeding 1984
Ph.D. University of Wisconsin-Madison, Meat & Animal Sciences/ Animal Breeding 1987
Post Doctoral Research University of Wisconsin-Madison Department of Dairy Science

Research Interests:

Research interests include analysis of genetic variation in reproduction and disease resistance in livestock and laboratory species and refinement of the bovine / human / mouse comparative map. A primary focus is identification of genes (quantitative trait loci or QTL) contributing to variation in bovine twinning rate. Use of markers linked with twinning rate QTL in selection programs will greatly facilitate increasing or decreasing twinning rate as deemed appropriate by a given cattle management system. Comparative mapping efforts are targeted to genomic regions harboring QTL and regions lacking comparative map data.

Twinner Cattle Research Website

Teaching:

• Animal Science 431: Beef Cattle Production, Fall, 1989 to present,
  co-taught with Dr. D. Schaefer     AS431 Home Page
• Shortcourse: Beef Cattle Management and Production, Spring, 1990 to present,
  co-taught with Dr. D. Schaefer
• Dairy Science 900: Seminar in Gene Mapping and Marker Assisted Selection,
  each semester: 1991 to present
• Animal Science 951 / Genetics 951: Seminar in Animal Breeding,
  Spring 1995, Fall 1998
• Animal Science 875, Strategies and Methods in Mapping Economic Trait
  Loci, Spring 1995, Spring 1998
• INTER-AG 288, Introduction to Undergraduate Research, each fall, co-taught with
  Dr. N.J. Benevenga,
• Dairy Science / Animal Science 360, Animal Breeding, Guest Lecturer, Spring,
  1990 to present

Awards:

Patent: U.S. Patent No. 5,759,772 -- Method for Determining the Sex of an Embryo. Issued June 2, 1998.

Outreach and Extension:

A workshop in genetic marker methods and applications is offered on a biannual basis to industry animal geneticists. This workshop provides hands-on experience with DNA technology in the laboratory and genetic marker data in the computer lab. The workshop is co-taught with Dr. Margaret Dentine of the Department of Dairy Science.

Back row: Brian Kirkpatrick, Hasan Koyun, John Woollard, Jon Bastiaansen, Ercan Kurar.
Front row: Jenny Che, Margaret Dentine, Jenifer Cruickshank, Becky Byla, Zixia Gu, Val Schutzkus

Consensus map

Comprehensive map

Marker genotypes by Laboratory (PDF format 65k)

Reference families. (PDF format 65k)

BTA24 Consensus Map:

Comprehensive map
Distances in cM (PDF format 70k)

Programs (SAS)--Calculating genotypic probabilities for Haley- Knott regression

Manual (PDF format 65k)
Example (PDF format 53k)
Run ( PDF format 36k)
Run Final ( PDF format 100k)
Run General (PDF format 91k)

Kim ES, Kirkpatrick BW. 2009. Linkage disequilibrium in the North American Holstein population.  Animal Genetics 40, 279–288.

Kim ES, Berger PJ, Kirkpatrick BW. 2009. Genome-wide scan for bovine twinning rate QTL using linkage disequilibrium.  Animal Genetics 40, 300–307.

Kim ES, Shi X, Cobanoglu O, Weigel K,. Berger PJ, Kirkpatrick BW.  2009.  Refined Mapping of Twinning Rate QTL on Bovine Chromosome 5.  Journal of Animal Science 87:835-843.

Morris CA, Wheeler M, Levet GL, Kirkpatrick BW.  2009.  A cattle family in New Zealand with triplet calving ability.  Journal of Heredity (submitted).

Kirkpatrick BW, Shi X, Shook GE, Collins MT.  2009.  Whole genome association study of susceptibility to infection by Mycobacterium avium subsp. paratuberculosis in Holstein cattle. Animal Genetics (submitted).

Bierman CD, Kim E-S, Shi X , Weigel K, Berger PJ, Kirkpatrick BW.  2009.  Validation of twinning rate whole genome association study results.  Animal Genetics (submitted).

Gonda MG, Kirkpatrick BW, Shook GE, Collins MT.  2007. Identification of a QTL Affecting Susceptibility to Mycobacterium avium ssp. paratuberculosis Infection on BTA20 in U.S. Holsteins.  Animal Genetics 38:389-396

Gonda MG, Chang YM, Shook GE, Collins MT, Kirkpatrick BW.  2006.  Genetic Variation of Johne’s Disease Susceptibility in U.S. Holsteins.  J. Dairy Sci. 89:1804-1812.

Greaser ML, Krzesinski PR, Warren CM, Kirkpatrick B,. Campbell KS Moss KS.  2006.  Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition Journal of Muscle Research and Cell Motility 26:325-332.

del Rio NS, Kirkpatrick BW, Fricke PM.  2006.  Observed frequency of monozygotic twinning in Holstein dairy cattle.  Theriogenology 66:1292-9.

Gonda MG, Chang YM, Shook GE, Collins MT, Kirkpatrick BW.  2006.  Effect of Mycobacterium paratuberculosis infection on production, reproduction, and health traits in U.S. Holsteins. Preventive Veterinary Medicine 80:103-119

Cobanoglu O, Berger PJ, Kirkpatrick BW.  2005.  Genome screen for twinning rate QTL in four North American Holstein families.  Animal Genetics 36:303-8.

Arias J, Kirkpatrick BW.  2004.  Mapping of bovine ovulation rate QTL; an analytical approach for three generation pedigrees.  Animal Genetics 35:7-13.

Cruickshank J, Dentine MR, Berger PJ, Kirkpatrick BW.  2004.  Evidence for quantitative trait loci affecting twinning rate in North American Holstein cattle.  Animal Genetics 35:206-212.

Gonda MG, Arias JA,. Shook GE, Gregory KE,. Kirkpatrick BW.  2004.  Identification of an ovulation rate QTL in cattle on BTA14 using selective DNA pooling and interval mapping.  Animal Genetics 35:298-304.

Gu Z, Gomez-Raya L, Våge DI, Elo K, Barendse W, Davis G, Grosz M, Erhardt G, Kalm E , Reinsch N, Kappes SM, Stone RT, Davis SK, Taylor JF .Kirkpatrick BW. 2000. Consensus and comprehensive linkage maps of bovine chromosome 7. Animal Genetics 31:206-209.

Kirkpatrick BW, Byla BM,. Gregory KE. 2000. Mapping quantitative trait loci for bovine ovulation rate. Mammalian Genome 11:136-139.

Gu Z, Womack JE, Kirkpatrick BW. 1999. A radiation hybrid map of bovine chromosome 7 and comparative mapping with human chromosome 19 p arm. Mammalian Genome 10:1112-1114

Larsen NJ, Hayes H, Bishop M, Davis SK, Taylor JF, Kirkpatrick BW. 1999. A comparative linkage and physical map of bovine chromosome 24 with human chromosome 18. Mammalian Genome 10:482-487.

Kirkpatrick BW,. Mengelt A, Schulman N. Martin ICA. 1998. Identification of quantitative trait loci for prolificacy and growth in mice. Mammalian Genome 9:97-102.

Gu Z, Womack JE, Kirkpatrick BW. 1998. Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7. Cytogenetics and Cell Genetics 79:225-7.

Taylor JF, Eggen A, Aleyasin A, Armitage SM, Barendse W, J.E. Beever, M.D. Bishop, R.A. Brenneman, B.M. Burns, S.K. Davis, K. Elo, B. Harlizius, S.M. Kappes, J.W. Keele, S.J. Kemp, B.W. Kirkpatrick, H.A. Lewin, R.Z.

Ma, R.A. McGraw, D. Pomp, R.T. Stone, Y Sugimoto, A.J. Teale, D. Vaiman, J. Vilkki, J.L. Williams, C.-C. Yeh and M.C. Zanotti. 1998. Report of the first workshop on the genetic map of bovine chromosome 1. Animal Genetics 29:228-235.

Casas-Carrillo, E. and B.W. Kirkpatrick. 1998. Regiones genomicas asociadas con crecimiento en cerdos. Veterinaria México 29:181-189.

Larsen, N.J., A. Eggen, B. Byla, L. Doud, M.D. Bishop, and B.W. Kirkpatrick. 1998. UW68, a polymorphic bovine microsatellite on chromosome 17. Animal Genetics 29:243.