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Marion Greaser, Professor                         


80% Research, 20% Instruction
Department of Animal Science;
Muscle Biology Laboratory
1805 Linden Drive West
Madison, WI 53706
Telephone: 608/262-1456
Fax: 608/265-3110
email: mgreaser@ansci.wisc.edu

PubMed citations

photo-Dr. Marion Greaser

Education Research Interests Awards Teaching Presentations/ Publications

Education:

B.S., Animal Science, Iowa State University 1960-1964
M.S., Biochemistry & Meat & Animal Science, joint, University of Wisconsin-Madison, Madison, Wisconsin 1964-1967
Ph.D., Biochemistry & Meat & Animal Science, joint, University of Wisconsin-Madison, Madison, Wisconsin 1967-1969
Postdoctorate, Muscle Biochemistry, Boston Biomedical Research Institute, Boston, MA 1969-1971
Assistant Professor, University of Wisconsin-Madison, 1971-1973
Associate Professor, University of Wisconsin-Madison,1973-1977
Professor,University of Wisconsin-Madison 1977-present
Director of Muscle Biology Laboratory, University of Wisconsin-Madison, 1997-2009

Research Interests:

Structure and function of muscle proteins, muscle growth and protein assembly, postmortem changes in muscle proteins, alternative splicing

Awards:

American Meat Science Assoc.--Distinguished Research Award 1981
American Heart Assoc. of Wisconsin -- Outstanding Researcher Award 1985
American Heart Assoc. of Wisconsin - Professional Practice Award 1987
American Society of Animal Science Award in Meat Research 2000
Who's Who in America 1986- present
Editorial Board - Journal of Food Science 1987-1992
Editorial Board - Meat Science 1992 - present
Editorial Board - Journal of Muscle Foods 1999 - 2002
NIH Physiology Study Section - 1997

Courses Taught

An Sci/Anat/Physiol 725 - Muscle Biology
An Sci 305 - Meat Science

Publications (of over 230 total)

Greaser, M.L. 2001. Identification of new repeating motifs in titin. Proteins 43:145-149.

K. Watanabe, P. Nair, D. Labeit, M. Kellermayer, M. Greaser, S. Labeit, and H. Granzier. 2002. Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J. Biol. Chem. 277:11549-11558.

Harris, S.P., C.R. Bartley, T.A. Hacker, K.S. McDonald, M.L. Greaser, P.A. Powers, and R.L. Moss. 2002. Hypertrophic cardiomyopathy in myosin binding protein-C knockout mice. Circ. Res. 90:594-601.

Yamasaki, R., Y. Wu, M. McNabb, M. Greaser, S. Labeit, and H. Granzier. 2002. Protein kinase A phosphorylates the cardiac-specific N2B domain of titin's extensible region and modulates passive tension in rat cardiac myocytes. Circ. Res. 90:1181-1188.

Torrealba, J.R., E. Lozano, M. Griffin, S. Stoker, K. McDonald, M. Greaser, and M.R.Wolff. 2002. Maximal ATPase activity and calcium sensitivity of reconstituted myofilaments are unaltered by the fetal troponin T re-expressed during human heart failure. J. Mol. Cell. Cardiol. 34:797-805.

Greaser, M.L., M. Berri, C.M. Warren, and P.E. Mozdziak. 2002. Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension. J. Muscle Res. Cell Motil. 23:471-480.

Harris, S.P., W.T. Heller, M.L. Greaser, R.L. Moss, and J. Trewhella. 2003. Solution structure of heavy meromyosin by small-angle scattering. J. Biol. Chem. 278:6034-6040.

Huang, C., Q. Zhou, P. Liang, M. Hollander, F. Sheikh , X. Li, M. Greaser, G. D. Shelton, S. Evans, and J.Chen. 2003. Short or long isoforms of Cypher can rescue lethality resulting from loss of Cypher function. J. Biol. Chem. 278:7360-7365.

Warren, C.M., P.R. Krzesinski, and M.L. Greaser. 2003. Vertical agarose gel electrophoresis and electroblotting of high molecular weight proteins. Electrophoresis 24:1695-1702.

Warren, C.M., M. C. Jordan, K. P. Roos, P. R. Krzesinski, and M. L. Greaser. 2003. Titin isoform expression in normal and hypertensive myocardium. Cardiovasc. Res. 59:86-94.

Chad M. Warren, C.M. and M.L. Greaser. 2003. Method for cardiac myosin heavy chain separation by SDS gel electrophoresis. Anal. Biochem. 320:149-151.

Ilian, M.A., R. Bickerstaffe and M.L. Greaser. 2003. Postmortem changes in myofibrillar-bound calpain 3 revealed by immunofluorescence microscopy. Meat Sci. 66:231-240.

Trombitás, K., Y. Wu, M. McNabb, M. Greaser, M.S.Z. Kellermayer, S. Labeit, and H . Granzier. 2003. Molecular basis of passive stress-relaxation in human soleus fibers: assessment of the role of immunoglobulin-like domain unfolding. Biophys. J. 85:3142-3153.

Ringkob, T.P., D.R. Swartz, and M.L. Greaser. 2004.  Light microscopy/image analysis of thin filament lengths utilizing dual probes on beef, chicken and rabbit myofibrils. J. Anim. Sci. 82:1445-1453.

Warren, C.M., P. R. Krzesinski, K. S. Campbell, R. L. Moss, and M. L. Greaser. 2004. Titin isoform changes in rat myocardium during development.  Mech. Dev. 121:1301-1312.

Barash, I.A., L.Mathew, M. Lahey, M.L. Greaser, and R.L. Lieber. 2005.  Muscle LIM protein plays both structural and functional roles in skeletal muscle. Am. J. Physiol. Cell Physiol. 289: C1312-20.

Greaser, M.L., P.R. Krzesinski, C.M. Warren, B. Kirkpatrick, K.S. Campbell, and R. L. Moss. 2005. Developmental changes in rat cardiac titin/connectin: transitions in normal animals and in mutants with a delayed pattern of isoform transition. J. Mus. Res. & Cell Motil 26:325-332.

Sammel, L.M., J.R. Claus, M.L. Greaser and M.P. Richards. 2006. Investigation of mechanisms by which sodium citrate reduces the pink color defect in cooked ground turkey.  Meat Sci. 72:585-595.

Duan, Y., DeKeyser, J.G., Damodaran, S., and Greaser, M.L. 2006. Studies on titin PEVK peptides and their interaction. Arch. Biochem. Biophys. 454:16-25.

Greaser, M.L., C. M. Warren, K. Esbona, W. Guo,Y. Duan, A. M. Parrish, P. R. Krzesinski, H. S. Norman, S. Dunning, D. P. Fitzsimons, and R. L. Moss. 2008. Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension. J. Molec. Cellul. Cardiol. 44:982-991.

Tong CW, Stelzer JE, Greaser ML, Powers PA, Moss RL. 2008. Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.Circ Res. 2008 Oct 24;103(9):974-82.

Mitov MI, Greaser ML, Campbell KS. 2009. GelBandFitter--a computer program for analysis of closely spaced electrophoretic and immunoblotted bands. Electrophoresis. 2009 Mar;30(5):848-51.

Greaser ML, Warren CM. 2009. Efficient electroblotting of very large proteins using a vertical agarose electrophoresis system. Methods Mol Biol. 2009;536:221-7.

Greaser ML. 2009. Stressing the giant: a new approach to understanding dilated cardiomyopathy. J Mol Cell Cardiol. 2009 Sep;47(3):347-9.

Guo W, Bharmal SJ, Esbona K, Greaser ML. 2010. Titin diversity--alternative splicing gone wild. J Biomed Biotechnol. 2010;2010:753675.

Rybakova IN, Greaser ML, Moss RL. 2011. Myosin binding protein C interaction with actin: characterization and mapping of the binding site. J Biol Chem. 2011 Jan 21;286(3):2008-16.

Thacker BE, Tomiya A, Hulst JB, Suzuki KP, Bremner SN, Gastwirt RF, Greaser ML, Lieber RL, Ward SR. 2012. Passive mechanical properties and related proteins change with botulinum neurotoxin A injection of normal skeletal muscle. J Orthop Res. 2012 Mar;30(3):497-502.

Li S, Guo W, Schmitt BM, Greaser ML. 2012. Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats. J Cell Biochem. 2012 Apr;113(4):1265-73.

Patel JR, Pleitner JM, Moss RL, Greaser ML. 2012. Magnitude of length-dependent changes in contractile properties varies with titin isoform in rat ventricles. Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H697-708.

Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M. 2012. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med. 2012 May;18(5):766-73.

Greaser ML, Warren CM. 2012. Protein electrophoresis in agarose gels for separating high molecular weight proteins. Methods Mol Biol. 2012;869:111-8.


 

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