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Mark Cook, Professor                  


Department of Animal Sciences
1064 Animal Science Bldg.
1675 Observatory Drive
Madison, WI 53706
Telephone: 608.262.7747
Fax: 608.262.5157
email: mcook@wisc.edu
Homepage: https://mywebspace.wisc.edu/mcook/web

PubMed citations


Education Research Awards Teaching Presentations/
Publications
Complete CV in PDF format      

Education:
Ph.D. Louisiana State University, Poultry Nutrition/ Immunology 1982
Postdoctoral Research: University of Wisconsin-Madison, Department of Poultry Science

Research:

My research focus is on the nutritional regulation of immune function.

Awards:

For further patent and licensing information, go to Wisconsin Alumni Research Foundation (WARF) webpage at: www.wisc.edu/warf.

Cook, M.E., and M.W. Pariza, 1995. Methods for preventing weight loss, reduction in weight gain, and anorexia due to immune stimulation. US Patent 5,430,066.

Cook, M.E., and M.W. Pariza, 1995. Method for increasing the efficiency of feed conversion in animals. US Patent 5,428,072.

Porter, W.P., I.W. Treichel, and M.E. Cook, 1999. Passive measurement of isotopes to monitor health. US Patent 5,912,178.

Cook, M.E., M.W. Pariza, K.N. Lee, and B.C. Wentworth, 1996. Method for controlling bird populations. US Patent 5504,114.

Cook, M.E., C.C. Miller, and J.L. Pimentel, 1998. CCK antibodies used to improve feed efficiency. US Patent 5,827,517.

Cook, M.E. and M.W. Pariza, 1998. Method of treating animals to maintain or increase CD-4 and CD-8 cell population. US Patent 5,827,885.

Cook, M.E., M.W. Pariza, and Y. Park, 1996. Method for reducing body fat in animals. US Patent: 5,554,646.

Cook, M.E., M.W. Pariza, X. Yang, and D. Devoney, 1997. Methods of treating animals to maintain or increase CD-4 and CD-8 cell populations. US Patent 5,674,901.

Cook, M.E., E.B. Cook, J.L. Stahl, F.M. Graziano, and M.W. Pariza, 1996. Methods of attenuating the allergic response in animals. US Patent 5,585,400.

Cook, M.E., and D.L. Jerome, 1998. Method of improving the growth or the efficiency of feed conversion of an animal and compositions for use therein. US Patent 5,725,873.

Cook, M.E., and M.W. Pariza, 1998. Methods of treating animals to maintain or enhance bone mineral content and compositions for use therein. US Patent 5,804,210.

Cook, M.E., M.W. Pariza, 1998. Dietetic foods containing conjugated linoleic acid. US Patent 5,760,082.

Cook, M.E., M.W. Pariza, and D.L. Jerome, 1998. Method for preventing skeletal problems in poultry. US Patent 5,760,083.

Cook, M.E., S. Kim, M.W. Pariza, D. DeVoney, 1999. Method of treating animals to enhance natural killer lymphocyte function. US Patent 5,914,346.

Cook, M.E., Y. Park, and M.W. Pariza, 1999. Method for controlling body fat and/or body weight in animals and pharmaceutical compositions for use therein. US Patent 5,855,917.

Cook, M.E., and M.W. Pariza, 1998. Method for maintaining an existing level of body fat and/or body weight. US Patent 5,814,663.

Cook, M.E., D.L. Jerome, M.W. Pariza, and D. Buege, 1998. Method for increasing fat firmness and improving meat quality in animals. Pending. US Patent 5,851,572.

Cook, M.E., C.C. Miller, and J.L. Pimentel, 1998. Novel compound to mimic a naturally occurring peptide effect. U.S. Patent 5814316.

Koegel, R.G., R.J. Straub, S. Austin-Phillips, and M.E. Cook, 1999. Animal feed compositions containing phytase derived from transgenic alfalfa and methods of use thereof. U.S. Patent 5900525.

Cook, M.E. and D.L. Jerome, 1999. Method of improving the growth or the efficiency of feed conversion of an animal and compositions for use therein. U.S. Patent 5,919,451.

Courses Taught:

Publications:

Cook, M.E., T.R. Scott, J.A. Hebert, and W.A. Johnson, 1982. Effects of blood sampling by cardiac puncture on subsequent body weights of boilers. Poultry Sci. 61:2506-2508.

Cook, M.E., and W.T. Springer, 1983. Effect of reovirus infection and dietary levels of selected vitamins on immunocompetence of chickens. Avian Dis. 27:367-377.

Cook, M.E., and M.L. Sunde, 1983. Performance of chicks fed diets composed of single ingredients or combinations of ingredients: A laboratory demonstration for undergraduates. World’s Poultry Sci. J. 40:207-214.

Cook, M.E., P.H. Patterson, and M.L. Sunde, 1984. Leg deformities: Inability to increase severity by increasing body weight of chicks and poults. Poultry Sci. 63:620-627.

Cook, M.E., W.T. Springer, and J.A. Hebert, 1984. Enhanced incidence of leg abnormalities in reovirus WVU 2937 infected chickens fed various dietary levels of selected vitamins. Avian Dis. 28:548-561.

Cook, M.E., W.T. Springer, K.M. Kerr, and J.A. Hebert, 1984. Severity of tenosynovitis in reovirus-infected chickens fed various dietary levels of choline, folic acid, manganese, biotin, or niacin. Avian Dis. 28:526-573.

Cook, M.E., M.L. Sunde, J.L. Stahl, and L.E. Hanson, 1984. Zinc deficiency in pheasant chicks fed practical diets. Avian Dis. 28(4):1102-1109.

Ameenuddin, S., M.L. Sunde, and M.E. Cook, 1985. Essentiality of vitamin D 3 and its metabolites in poultry nutrition: A review. World’s Poultry Sci. Assn. J. 41:52-63.

Dafwang, I.I., M.E. Cook, M.L. Sunde, and H.R. Bird, 1985. Bursal, intestinal, and spleen weights and antibody response of chicks fed subtherapeutic levels of dietary antibiotics. Poultry Sci. 64:634-639.

Ameenuddin, S., M.L. Sunde, H.F. DeLuca, and M.E. Cook, 1986. Excessive cholecalciferol in a layers diet: Decline in some aspects of reproductive performance and increased bone mineralisation of progeny. Brit. Poultry Sci. 27:671-677.

Crenshaw, T.D., M.E. Cook, J. Odle, and R.E. Martin, 1986. Effect of nutritional status, age at weaning, and room temperature on growth and systemic immune response of weanling pigs. J. Anim. Sci. 63:1845-1853.

Dafwang, I.I., M.E. Cook, D.J. Pringle, and M.L. Sunde, 1986. Nutritional value of aerobically fermented poultry manure and offal (Fermway) for broiler chicks. Poultry Sci. 65:1765-1770.

Patterson, P.H., M.E. Cook, T.D. Crenshaw, and M.L. Sunde, 1986. Mechanical properties of the tibiotarsus of broilers and poults loaded with artificial weight and fed various dietary protein levels. Poultry Sci. 65:1357-1364.

Stahl, J.L., M.E. Cook, and M.L. Sunde, 1986. Zinc supplementation: Its effect on egg production, feed conversion, fertility, and hatchability. Poultry Sci. 65:2104-2109.

Bates, D.P., L.E. Hanson, M.E. Cook, B.C. Wentworth, M.L. Sunde, and J.J. Bitgood, 1987. Lighting and sex ratio for breeding ringnecked pheasants in confined housing. Poultry Sci. 66:605-612.

Dafwang, I.I., M.E. Cook, and M.L. Sunde, 1987. Interaction of dietary antibiotic supplementation and stocking density on broiler chick performance and immune response. Brit. Poultry Sci. 28:47-55.

Gildersleeve, R.P., D.G. Satterlee, T.R. Scott, D.I. McRee, C.R. Parkhurst, M.E. Cook, 1987. Hematology of Japanese quail selected for high or low serum corticosterone responses to complex stressor. Comp. Biochem. Physiology: Physiology A 86A:569-573.

Greger, J.L., M.L. Storey, J.L. Stahl, M.E. Cook, S.E. Gentry-Roberts, and J.C. Lynds, 1987. Zinc, iron and copper interactions in humans, rats and chicks. Tr. Elem. Nutr. in Man and Animals 6:231-232.

Pimentel, J.L., and M.E. Cook, 1987. Suppressed humoral immunity in chicks fed diets deficient in sodium, chloride, or both sodium and chloride. Poultry Sci. 66:2005-2010.

Tsiagbe, V.K., M.E. Cook, A.E. Harper, and M.L. Sunde, 1987. Assessment of softness properties of feathers. Poultry Sci. 66:1600-1602.

Tsiagbe, V.K., M.E. Cook, A.E. Harper, and M.L. Sunde, 1987. Efficacy of cysteine in replacing methionine in the immune responses of broiler chicks. Poultry Sci. 66:1138-1146.

Tsiagbe, V.K., M.E. Cook, A.E. Harper, and M.L. Sunde, 1987. Enhanced immune responses in broiler chicks fed methionine-supplemented diets. Poultry Sci. 66:1147-1154.

Tsiagbe, V.K., R.J. Straub, M.E. Cook, A.E. Harper, and M.L. Sunde, 1987. Critical vitamin supplementation of broiler diets high in alfalfa juice protein. Poultry Sci. 66:1771-1778.

Tsiagbe, V.K., R.J. Straub, M.E. Cook, A.E. Harper, and M.L. Sunde, 1987. Formulating wet alfalfa juice protein concentrate diets for chicks. Poultry Sci. 66:1023-1027.

Chu , Q., M.E. Cook, W. Wu, and E.B. Smalley, 1988. Research Note: Immune and bone properties of chicks consuming corn contaminated with a Fusarium that induces dyschondroplasia. Avian Dis. 32:132‑136.

Pimentel, J.L., and M.E. Cook, 1988. Improved growth in the progeny of hens immunized with jackbean urease. Poultry Sci. 67:434-439.

Ricke , S.C. , D.M. Schaefer , M.E. Cook, and K.H. Kang, 1988. Differentiation of ruminal bacterial species by enzyme-linked immunosorbent assay using egg yolk antibodies from immunized chicken hens. Appl. Envir. Micro. 54:596-599.

Tsiagbe, V.K., M.E. Cook, A.E. Harper, and M.L. Sunde, 1988. Alterations in phospholipid composition of egg yolks from laying hens fed choline- and methionine-supplemented diets. Poultry Sci. 67:1717-1724.

Stahl, J.L., M.E. Cook, and J.L. Greger, 1989. Zinc, iron and copper content of eggs from hens fed varying levels of zinc. J. Food Composition 1:309-315.

Stahl, J.L., M.E. Cook, M.L. Sunde, and J.L. Greger, 1989. Enhanced humoral immunity in progeny chicks from hens fed practical diets supplemented with zinc. Appl. Agric. Res. 4:86-89.

Stahl, J.L., J.L. Greger, and M.E. Cook, 1989. Zinc, copper, and iron utilisation by chicks fed various concentrations of zinc. Brit. Poultry Sci. 30:123-134.

Burdsall, H.H., M. Banik, and M.E. Cook, 1990. Serological differentiation of three species of Armillaria and Lentinula edodes by enzyme-linked immunosorbent assay using immunized chickens as a source of antibodies. Mycologia 82:415-423.

Poernama, F., S.A. Schreyer, J.J. Bitgood , M.E. Cook, and A.D. Attie, 1990. Spontaneous high density lipoprotein deficiency syndrome associated with a Z-linked mutation in chickens. J. Lipid Res. 31:955-963.

Schrank, C.S., M.E. Cook, and W.R. Hansen, 1990. Immune response of mallard ducks treated with immunosuppressive agents: Antibody response to erythrocytes and in vivo response to phytohemagglutinin-P. J. Wildlife Dis. 26:307-315.

Stahl, J.L., J.L. Greger, and M.E. Cook, 1990. Breeding-hen and progeny performance when hens are fed excessive dietary zinc. Poultry Sci. 69:259-263.

Wu, W., M.E. Cook, and E.B. Smalley, 1990. Prevention of thiram-induced dyschondroplasia by copper. Nutr. Res. 10:555-557.

Wu, W., P.E. Nelson, M.E. Cook, and E.B. Smalley, 1990. Fusarochromanone production by Fusarium isolates. Appl. Envir. Micro. 56:2989‑2993.

Cook, M.E., 1991. Nutrition and the immune response of the domestic fowl. CRC Poultry Biology 3:167-189.

Cook, M.E., 1991. Mycotoxin and nutrient interactions. 40th Western Dis. Conf., pp. 51-54.

Orth, M.W., D.A. Martinez , M.E. Cook, and A.C. Vailas, 1991. Non-reducible crosslink formation in tibial dyschondroplastic growth plate cartilage from broiler chicks fed homocysteine. Biochem. Biophys. Res. Comm. 179:1582-1586.

Payne, C., M.E. Cook, T.M. Ellis, and R.E. Hams, 1991. ELISA testing of U.S. breeders and layers for big liver and spleen disease (BLS). 40th Western Dis. Conf., pp. 216-218.

Pimentel, J.L., M.E. Cook, and J.L. Greger, 1991. Bioavailability of zinc-methionine for chicks. Poultry Sci. 70:1637-1639.

Pimentel, J.L., M.E. Cook, and J.L. Greger, 1991. Immune response of chicks fed various levels of zinc. Poultry Sci. 70:947-954.

Pimentel, J.L., M.E. Cook, and J.M. Jonsson, 1991. Research Note: Increased growth of chicks and poults obtained from hens injected with jackbean urease. Poultry Sci. 70:1842-1844.

Poernama, F., R. Subramanian, M. Cook, and A. Attie, 1991. High density lipoprotein deficiency syndrome in chickens is not associated with an increased susceptibility to atherosclerosis. Arteriosclerosis thrombosis 12:601-607.

Wu, W., M.E. Cook, and E.B. Smalley, 1991. Decreased immune response and increased incidence of tibial dyschondroplasia caused by Fusaria grown on sterile corn. Poultry Sci. 70:293‑301.

Bai, Y., M.L. Sunde, and M.E. Cook, 1992. Wheat middlings as an alternate feedstuff for laying hens. Poultry Sci. 71:1007-1014.

Orth, M.W., Y. Bai, I.H. Zeytun, and M.E. Cook, 1992. Excess levels of cysteine and homocysteine induce tibial dyschondroplasia (TD) in broiler chicks. J. Nutr. 122:482-487.

Pimentel, J.L., M.E. Cook, and J.L. Greger, 1992. Anemia induced by ingestion of excess zinc in chicks: Importance of red blood cell turnover. J. Nutr. Biochem. 3:146-150.

Pimentel, J.L., J.L. Greger, M.E. Cook, and J.L. Stahl, 1992. Iron metabolism in chicks fed various levels of zinc and copper. J. Nutr. Biochem. 3:140-145.

Banik, M.T., J.A. Paul, H.H. Burdsall, and M.E. Cook, 1993. Serological differentiation of two forms of Phellinus weirii. Mycologia 85:605-611.

Cook, M.E., C.C. Miller, Y. Park, and M. Pariza, 1993. Immune modulation by altered nutrient metabolism. Nutritional control of immune-induced growth depression. Poultry Sci. 72:1301-1305.

Orth, M.W., D.A. Martinez , M.E. Cook, and A.C. Vailas, 1993. The presence of lysylpyridinoline in the hypertrophic cartilage of newly hatched chicks. Biochimica Biophys. Acta 1157:229‑232.

Wu, W., M.E. Cook, Q. Chu, and E.B. Smalley, 1993. Tibial dyschondroplasia of chickens induced by fusarochromanone, a mycotoxin. Avian Dis. 37:302‑309.

Bai, Y., and M.E. Cook, 1994. Histological study of tibial dyschondroplasia from light-type chicks fed cysteine-supplemented diets. Avian dis. 38:557-562.

Bai, Y., M.L. Sunde, and M.E. Cook, 1994. Egg production of laying hens before and after force-molting is not correlated. Appl. Poultry Res. 3:127-132.

Bai, Y. M.L. Sunde, and M.E. Cook, 1994. Molybdenum but not copper counteracts cysteine-induced tibial dyschondroplasia in broiler chicks. J. Nutr. 124:588-593.

Chin, S.F., J.M. Storkson, K.J. Albright, M.E. Cook, and M.W. Pariza, 1994. Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J. Nutr. 124:2344-2349.

Cook, M.E., Y. Bai, and M. Orth, 1994. Factors influencing growth plate cartilage turnover. Poultry Sci. 73:889-896.

Miller, C.C., and M.E. Cook, 1994. Evidence against the induction of immunological tolerance by feeding antigens to chickens. Poultry Sci. 73:106-112.

Miller, C.C., Y. Park, M.W. Pariza, and M.E. Cook, 1994. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem. Biophys. Res. Comm. 198:1107‑1112.

Orth, M.W., and M.E. Cook, 1994. Avian tibial dyschondroplasia: a description of the growth plate disease as well as the conditions that induce it. Vet. Pathol. 31:403-414.

Orth, M.W., R.M. Leach, A.C. Vailas, and M.E. Cook, 1994. Non‑reducible collagen cross‑linking in cartilage from broiler chickens with tibial dyschondroplasia. Avian Dis. 38:44‑49.

Chu , Q., W. Wu , M.E. Cook, and E.B. Smalley, 1995. Induction of tibial dyschondroplasia and suppression of cell‑mediated immunity in chickens by Fusariumoxysporum grown on sterile corn. Avian Dis. 39:100-107.

Hatch, K.A., K.A. Sacksteder, I.W. Treichel, M.E. Cook, and W.P. Porter, 1995. Early detection of catabolic state via change in 13C/ 12C ratio of blood protein. Biochem. Biophys. Res. Comm. 212:719-726.

Wages, D.P., M.D. Ficken , M.E. Cook, and J. Mitchell, 1995. Salt toxicosis in commercial turkeys. Avian Dis. 39:158-161.

Chu , Q., W. Wu , M.E. Cook, and E.B. Smalley, 1996. Elevated plasma glycosaminoglycans in chickens with tibial dyschondroplasia induced by a Fusarium oxysporum isolate. Avian Dis. 40:715-719.

Cook, M.E., 1996. Diet-induced immunosuppression. Pages 317-328 in: Poultry Immunology. T.F. Davison, T.R. Morris, and L.N. Payne, ed. Carfax Publishing Co., Oxfordshire, England.

Dafwang, I.I., M.L. Sunde, M.E. Cook, D.M. Schaefer, S.C. Ricke, D.J. Pringle, 1996. Effect of antibiotics and water quality on the growth, intestinal characterisitics and bacterial population of broiler chicks. Nigerian Journal of Animal Production. 23(2): 116-23.

Li, G., M.E. Cook, and W. Wu, 1996. Reduction of ferricyanide by thiamine or thiamine pyrophosphate. Biochem. Biophy. Res. Comm. 226:187-192.

Wu., M.E. Cook, F.S. Chu, T. Buttles, J. Hunger, and P. Sutherland, 1997. Case study of bovine dermatitis caused by oat straw infected with Fusarium sporotrichioides. Vet. Rec. 140:399-400.

Park, Y., K. J. Albright, W. Liu, J. M. Storkson, M. E. Cook and M. W. Pariza, 1997. Effect of Conjugated Linoleic Acid on Body Composition in Mice. Lipids. 32:853-858.

Cook, M.E. and M. Pariza, 1998. The Role of Conjugated Linoleic Acid (CLA) in Health. International Dairy J. 8:459-462.

Cook, M.E., 1999. Nutritional Effects on Vaccination. In: Veterinary Vaccines and Diagnostics (ed. R. D. Schultz). Advances in Veterinary Medicine Vol. 41: 53-59.

Cook, M.E., D. DeVoney, B. Drake, M.W. Pariza, L. Whigham, and M. Yang, 1999. Dietary control of immune-induced cachexia conjugated linoleic acid and immunity. In: Advances in Conjugated Linoleic Acid Research, Volume 1. (editors M.P. Yurawecz, M.M. Mossaba, J.K.G. Kramer, M.W. Pariza and G.J. Nelson) pp 226-237.

Park, Y., K. J. Albright, J. M. Storkson, W. Liu, M. E. Cook, and M. W. Pariza, 1999. Changes in body composition in mice during feeding and withdrawl of dietary conjugated linoleic acid. J. Lipids. Lipids 34: 243-248.

Pariza, Michael W., Yeonwha Park and Mark E. Cook, 1999. Conjugated Linoleic Acid and the Control of Cancer and Obesity. Toxicological Sciences. Toxicological Sciences. 52(Supplement): 107-110.

Pariza, M.W., Y. Park and M.E. Cook, 2000. Mechanisms of action of conjugated linoleic acid. Evidence and speculation. Proc. Soc. Exptl. Biol. Med. 223: 8-13.

Cook, M.E., 2000. Skeletal deformities and their causes. Poultry Science 79:982-984.

Park, Y., J. Storkson, J. Ntambi, M.E. Cook, C.J. Sih and M.W. Pariza, 2000 Inhibition of hepatic stearoyl-CoA desaturase activity by trans 10, cis 12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta. 1486:285-292.

Whigham, L.D., E.B. Cook, J.L. Stahl, R. Saban, D.E. Bjorling, M.W. Pariza and M.E. Cook, 2001. Conjugated linoleic acid reduces antigen-induced histamine and prostaglandin E 2 release from sensitized guinea pig trachea. Am. J. Physiol. Regulatory. Integrative Comp. Physiol. 280: R908-R912

Yang, M., M.W. Pariza , M.E. Cook, 2000. Dietary linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse. Immunopharma. Immunotox. 22:433-449.

Cook, M.E., 2000. The interplay between modern management practices and the chicken: how immune response and the physiological mechanism for growth and feed efficiency have adapted over time. Where do we go from here. In: Biotechnology in the Animal Feed Industry (eds., T.P. Lyons and K.A. Jacques). Nottingham University Press, pp 97-110.

Dhurandhar, N.V., B.A. Israel, J.M. Kolesar, G.F. Mayhew, M.E. Cook, and R.L. Atkinson, 2000. Increased adiposity in animals due to a human virus. Intl. J. Obesity 24:989-997.

Whigham, L.D., M.E. Cook, and R.L. Atkinson, 2000. Conjugated linoleic acid: implications for human health. Pharmacological Res. 42:503-510.

Stahl, J.L., E.B. Cook, M.A. Pariza, M.E. Cook, and F.M. Graziano, 2001. Effect of l-tryptophan supplementation on eosinophils and eotaxin in guinea pigs. Proc. Soc. Exptl. Biol. Med. 226: 177-184.

Aydin, R., M.W. Pariza, and M.E. Cook, 2001. Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. J. Nutr 131:800-806.

Turnock, L., M Cook, H. Steinberg, and C. Czuprynski, 2001. Dietary supplementation with conjugated linoleic acid does not alter resistance of mice to Listeria monocytogenes infection. Lipids 36:135-138.

Dhurandhar, N.V, B.A. Israel, J.M. Kolesar, G. Mayhew, M.E. Cook, and R.L. Atkinson. 2001. Transmissibility of adenovirus-induced adiposity in a chicken model. Intnl. J. Obesity. 25:990-996.

Pariza, M.W., Y. Park, and M.E. Cook. 2001. The biologically active isomers of conjugated linoleic acid. Progress Lipids Res. 40:283-298.

Whigham, L. D., A. Higbee, D. E. Bjorling, Y. Park, M.W. Pariza, and M. E. Cook. 2002. Conjugated linoleic acid reduces anti-induced prostaglandin and leukotriene release from sensitized guinea pig lung trachea, and bladder as measured by HPLC-tandem mass spectrometry. Am. J. Physiol. Regulatory. Integrative Comp. Physiol. 282:R1104-1112.

Cook,M. E. 2002. Regulation of eicosanoid pathways: A pathway to health and development. Pakistan J. Nutr. 1:103-105.

Attie, A. D., Y Hamon, A. R. Brooks-Wilson, M.P. Gray-Keller, M. L. E. MacDonald, V. Rigot, A. Tebon, L. Zhang, J. D. Mulligan, R. R. Singaraja, J. J. Bitgood, M. E. Cook, J. J. P Kastelein, G. Chimini, and M. R. Hayden. 2002. Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J Lipid Res. 43:1610-1617.

Cook, M. E., D. Butz, G. Li, M. W. Pariza, L. Whigham, and M. Yang. 2003. Conjugated linoleic acid enhances immune responses, but protects against the collateral damage of immune events. In: Advances in Conjugated Linoleic Acid Research,Volume 2, J. Sebedio, W. W. Christie, and R. Adlof, editors, AOCS Press, Champaign, IL, pp., 283-291.

Yang, M. and M. E. Cook. 2003. Dietary conjugated linoleic acid decreased cachexia, macrophage TNF a production and modifies splenocyte cytokines production. Exptl Biol. Med. 228:51-58.

Yang, M., and M. E. Cook. 2003. Dietary conjugated linoleic acid decreased weight loss and extended survival following the onset of kidney failure in NZB/W F1 mice. Lipids 38:21-24.

Aydin, R. and M. E. Cook. 2004. The effect of dietary conjugated linoleic acid on egg yolk fatty acids and hatchability in japanese quail. Poultry Sci. 83:2016-2022.

Cook, M.E. 2004. Antibodies:alternatives to antibiotics in improving growth and feed efficiency. Appl. J. Poultry Res. 13:106-119.

Aydin, R. and M.E. Cook. 2005. The influence of conjugated linoleic acid enriched tallow on egg hatchability and quality in chicken. Intl. J. Poultry Sci. 4:536-542.

Butz DE, Li G, Cook ME. 2005. 10t, 12t-conjugated linoleic acid induces compensatory growth after immune challenge. J Nutr Biochem 17:735-741.

Clark, W.D., E.L. Smith, K.A. Kim, J.R. Paul-Murphy, P. Muir, and M. E. Cook. 2005. Osteocyte apoptosis and osteoclast-like cell appearance in chicken radii following osteotom y. Calcif Tissue Int 77:327-336.

Graves, E., A. Hitt, M.W. Pariza, M.E. Cook, and DE. O. McCarthy. 2005. Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res. Nurs. Health 28:48-55.

Li G, Barnes D, Butz D, Bjorling D and Cook ME. 2005 10t, 12t-conjugated linoleic acid inhibits lipoplysaccharide-induced cyclooxygenase expression in vitro and in vivo. J Lipid Res 46:2134-2142.

Li G, Barnes D, Butz D, Bjorling D and Cook ME. 2005 10t, 12t-conjugated linoleic acid inhibits lipoplysaccharide-induced cyclooxygenase expression in vitro and in vivo. J Lipid Res 46:2134-2142.

Aydin, R., and Mark E. Cook. 2006. Dietary conjugated linoleic acid to control the population of wild bird species considered a pest. J. Wildlife Manage. 70:1786-1788.

Butz DE, Li G, Cook ME. 2006. t10,c12 Conjugated linoleic acid induces compensatory growth after immune challenge. J Nutr Biochem 17:735-741.

Li G, Dong B, Butz DE, Park Y, Pariza MW, Cook ME. 2006. NF-kappaB independent inhibition of lipopolysaccharide-induced cyclooxygenase by a conjugated linoleic acid cognate, conjugated nonadecadienoic acid. Biochim Biophys Acta 1761:969-972.

Li G, Butz D, Dong B, Park Y, Pariza MW, Cook ME. 2006. Selective conjugated fatty acids inhibit guinea pig platelet aggregation. Eur J Pharmacol 545:93-99.

Butz DE, Li G, Huebner SM, Cook ME. 2007. A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis. Am J Physiol Regul Integr Comp Physiol. 293:R669-R676.

Park, Y., M. Yang, J.M. Storkson, K.J. Albright, W. Liu, M.E. Cook, M.W. Pariza. 2007. Effects of conjugated linoleic acid isomers on serum tumor necrosis factor-a concentration in mice. J. Food Biochem. 31:252-265

Aydin, R., and M.E. Cook. 2008. The effects of dietary conjugated linoleic acid alone or in combination with linoleic acid and oleic acid on fatty acid composition of egg yolk, embryo mortality and chick yolk sac content retention in chickens. An. Feed. Sci. Technol. 149:125-134

Scanes, C.G., S.A. Cutler, R.W. Griffith, M. Yang, and M.E. Yang. 2008. Effects of egg antibody to components of inflammatory activation (phospholipase a2 and Toll like receptor 4) on the response of young turkeys to Salmonella typhimurium challenage. Avian Biol. Res. 1:167-175.

Trott DL, Hellestad EM, Yang M, Cook ME. 2008. Additions of killed whole cell bacteria preparations to Freund complete adjuvant alter laying hen antibody response to soluble protein antigen. Poult Sci 87:912-917.

Cook ME, and Trott DL. 2009. IgY-Immune component of eggs as a source of passive immunity for animals and humans. World Poultry Sci. accepted.

Leon VA, Worzalla SP, and Cook ME. 2009. Evidence of conjugated linoleic acid-induced embryonic mortality that is independent of egg storage conditions and changes in egg relative fatty acids. Poultry Sci. accepted.

Trott, DL, Yang Y, Gonzalez J, Larson AE, Tepp WH, Johnson EA, and Cook ME. 2009. Egg yolk antibodies for detection and neutralization of Clostridum botulinum toxin. J Food Protect. In press.

Leone VA, Worzalla SP, Cook ME. 2009. Body compositional changes and growth alteration in chicks from hens fed conjugated linoleic acid. Lipids 44:437-447.



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