Stem cells in predictive toxicology

Predictive toxicology is the evaluation of chemicals that result in adverse effects to human health. We develop toxicology models with embryonic stem cells to determine teratogenic and somatic toxicity of chemicals and drugs during early development and adulthood.

Gabriela Gebrin Cezar
DVM, Ph.D.
Assistant Professor

Department of Animal Sciences
1675 Observatory Drive
Madison, WI 53705
608-263-4307
ggcezar@wisc.edu

Preclinical Safety

Epigenetics has a determinant role in cellular differentation and plasticity. Our Laboratory studies epigenetics during hESC differentiation and how it affects tumorogenesis.

Colony of undifferentiated H1 embryonic stem cells in culture.

G.Cezar and J.Quam

Laser capture microscopy of stem cells

Heterogeneity is a limitaion to the generation of enriched cells from ES cells for in vitro models of disease. In pioneer studies, we have shown that photonics applications enable the isolation and enrichment of ES-cell derived cell types.